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Effect of ponsinomycin on cyclosporin pharmacokinetics

โœ Scribed by W. Couet; B. Istin; P. Seniuta; D. Morel; L. Potaux; J. B. Fourtillan

Publisher
Springer
Year
1990
Tongue
English
Weight
284 KB
Volume
39
Category
Article
ISSN
0031-6970

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โœฆ Synopsis

The influence of treatment with ponsinomycin, a new macrolide antibiotic, on the pharmacokinetics of cyclosporin A has been studied in 10 renal transplant patients. The pharmacokinetics of cyclosporin A was investigated at steady state, before and during treatment with ponsinomycin. On average, the blood levels of cyclosporin A were doubled by the macrolide, possibly due to a decrease in elimination or/and to an increase in absorption. Ponsinomycin should be use very carefully in patients treated with cyclosporin A.

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