Effect of cyclosporine and irradiation on experimental pancreatic allografts in the primate

✍ Scribed by Dr. Don F. Du Toit; Jacobus J. Heydenrych; Ben Smit; Theuns Zuurmond; Gabriel Louw; Daniel Els; Lida Baker; André Wlideman; Sonia Wolfe-Coote; Looraine Du Toti; Henry Davids; Wilhelm Groenewald; Emuel Van Der Merwe; Stephen Pistorius

• Publisher: John Wiley and Sons
• Year: 1988
• Tongue: English
• Weight: 429 KB
• Volume: 37
• Category: Article
• ISSN: 0022-4790
• DOI: 10.1002/jso.2930370318

✦ Synopsis

The present study assessed the effectiveness of cyclosporine (CSA) and subtotal marrow irradiation (TL1) alone, and CSA in combination with TL1 in a primate segmental pancreatic allotransplantation model. Continous administration of CSA 25 mg/kg/day and 50 mg/kg/day resulted in mean graft survival of 21.5 days and 24.5 days, respectively. Administration of fractionated TL1 800 rad (8 Gy) and 1, OOO rad (10 Gy) alone resulted in mean graft survival of 13.3 days and 14.5 days, respectively. Of 20 animals that received TL1 1 ,OOO rad (10 Gy) and CSA 25 mg/kg/ day orally for 5 days then 10 mg/kg/day intramuscularly indefinitely, 3 had graft survival of > 100 days. Likewise, of a group of 15 animals that received TLl 800 rad (8 Gy) and combined indefinite administration of CSA, 6 had graft survival of > 100 days. Although CSA and TL1 administration alone produced modest pancreatic allograft survival, a combination of ILl (800 or 1, OOO rad) and CSA resulted in highly significant segmental pancreatic allograft survival in the primate.