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Synergistic effect of rapamycin and cyclosporine in prevention of acute kidney allograft rejection in the mouse

✍ Scribed by Shijie Qi; Dasheng Xu; Junzheng Peng; Dingyi Liu; Huifang Chen

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
49 KB
Volume
19
Category
Article
ISSN
0738-1085

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✦ Synopsis

The effect of rapamycin (RAPA) and cyclosporine A (CsA) monotherapy and combination therapy was examined in prevention of kidney allograft rejection in the mouse. Both drugs were administered orally for up to 14 days in BALB/c (H-2 d ) to C57BL/6 (H-2 b ) mice strong combination. Six groups were treated with RAPA and/or CsA. This study shows that con-comitant therapy of RAPA and CsA produces strong synergistic interaction in prolonging renal allograft survival in mice when compared with monotherapy of RAPA or CsA.

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