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Effect of culture temperature on follicle-stimulating hormone production by Chinese hamster ovary cells in a perfusion bioreactor

โœ Scribed by Sung Kwan Yoon; Yong-Ho Ahn; Myeong Hyeon Jeong


Publisher
Springer
Year
2007
Tongue
English
Weight
176 KB
Volume
76
Category
Article
ISSN
1432-0614

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โœ Sung Kwan Yoon; Sang Lim Choi; Ji Yong Song; Gyun Min Lee ๐Ÿ“‚ Article ๐Ÿ“… 2004 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 773 KB

To investigate the effect of culture pH in the range of 6.85 -7.80 on cell growth and erythropoietin (EPO) production at 32.5 and 37.0jC, serum-free suspension cultures of recombinant CHO cells (rCHO) were performed in a bioreactor with pH control. Lowering culture temperature from 37.0 to 32.5jC su