𝔖 Bobbio Scriptorium
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Effect of chlorination on the anticonvulsant activity of phenobarbital

✍ Scribed by Ewart A. Swinyard; James T. Miyahara; Louis S. Goodman

Publisher
John Wiley and Sons
Year
1963
Tongue
English
Weight
299 KB
Volume
52
Category
Article
ISSN
0022-3549

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✦ Synopsis

The lethal doses, neurotoxic doses, anticonvulsant potencies, and protective indices for two chlorinated barbiturates, 5-(4-chlorophenyl)-5-ethylbarbituric acid (monochloro) and 5-(3,4-dichlorophenyl)-5-ethylbarbituric acid (dichloro), were determined in mice and the results compared with similar values concomitantly determined for phenobarbital. Chlorination was found to delay markedly the time for peak anticonvulsant effect and to prolong duration of action. The lethal dose for

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