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Effect of smoking on single dose pharmacokinetics of phenobarbital

✍ Scribed by A. Mirfazaelian; F. Jahanzad; M. Tabatabaei-far; H. Farsam; M. Mahmoudian

Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
70 KB
Volume
22
Category
Article
ISSN
0142-2782

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

In order to determine interaction of smoking with single dose pharmacokinetics of phenobarbital, a 60 mg tablet of the drug was given to 12 healthy male subjects in two groups (6 smokers and 6 non‐smokers) in a double blind study. An HPLC method using UV detection was developed to assess phenobarbital in plasma of the subjects. Pharmacokinetic parameters were calculated and compared in the two groups. Pharmacokinetic parameters of the two groups were not significantly different in the two groups (p<0.05). The results show no considerable effect of cigarette smoking on phenobarbital pharmacokinetics, which is in agreement with enzyme studies performed previously. Copyright Β© 2001 John Wiley & Sons, Ltd.

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