Insulin-like growth factor binding protein (IGFBP)-3 effects proliferation and differentiation of numerous cell types by binding to insulin-like growth factors (IGF) and attenuating their activity or by directly affecting cells in an IGFindependent manner. Consequently, IGFBPs produced by specific c
β¦ LIBER β¦
Effect of Breast Surgery on Serum Levels of Insulin-Like Growth Factors (IGF-I, IGF-II, and IGF Binding Protein-3) in Women With Benign and Malignant Breast Lesions
β Scribed by Ian M. Holdaway; Anne E. Lethaby; Barbara H. Mason; Vijay Singh; John E. Harman; Murray MacCormick; Ian D. Civil
- Publisher
- Springer
- Year
- 2001
- Tongue
- English
- Weight
- 65 KB
- Volume
- 8
- Category
- Article
- ISSN
- 1068-9265
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## Abstract Biologic evidence suggests substantial effect of insulinβlike growth factor (IGF)βI in mammary cell carcinogenesis. However, controversy remains regarding the association between circulating IGFβI levels and the risk of premenopausal breast cancer in epidemiologic studies. In addition,