Cancer risk factors associated with insulin-like growth factor (IGF)-I and IGF-binding protein-3 levels in healthy women: effect modification by menopausal status
โ Scribed by Benjamin B. E. Barnes; Jenny Chang-Claude; Dieter Flesch-Janys; Ralf Kinscherf; Martina Schmidt; Tracy Slanger; Gabriel Bonaterra; Karen Steindorf
- Publisher
- Springer Netherlands
- Year
- 2009
- Tongue
- English
- Weight
- 251 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0957-5243
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Insulin-like growth factor-I (IGF-I) has mitogenic and anti-apoptotic properties and has been implicated in the development of breast, colorectum, prostate and lung cancer. IGF binding proteins (IGFBPs) are not only carrier proteins for IGFs but also hold a central position in IGF ligand-receptor in