Effect of apolipoprotein E polymorphism on bile lipid composition and cholesterol gallstone formation
โ Scribed by K. Hasegawa; S. Terada; K. Kubota; H. Itakura; H. Imamura; S. Ohnishi; M. Makuuchi
- Book ID
- 117372114
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 166 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0168-8278
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๐ SIMILAR VOLUMES
Patients with multiple cholesterol gallstones are at increased risk of recurrence after nonsurgical therapy, possibly because of fast biliary cholesterol crystallization. Serum apolipoprotein E4 (apo E4) is a risk factor for primary cholesterol gallstone formation as well as recurrence. We examined
Duodenal bile obtained from patients with gallstones who were acutely infused with chenodeoxycholic acid, ursodeoxycholic acid, or cholic acid were examined for the propensity toward the formation of a liquid crystalline mesomorphic phase when cholesterol gallstones were incubated in these bile acid
In five patients with radiolucent gallstones, the effect of ursodeoxycholic acid (Urso) in doses of 250,500, 750, 1,000, and 1,250 mg per day on biliary lipid and bile acid composition was studied. Biliary cholesterol decreased from 8.8 f 0.8 mole% to 4.4 f 0.2 mole% at 500 mg Urso per day (7.1 mg p