Mesophase formation during cholesterol gallstone dissolution in human bile: Effect of bile acid composition

✍ Scribed by C. C. Su; W. I. Higuchi; I. T. Gilmore; R. G. Danzinger; A. F. Hofmann

• Publisher: John Wiley and Sons
• Year: 1984
• Tongue: English
• Weight: 235 KB
• Volume: 73
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600730834

✦ Synopsis

Duodenal bile obtained from patients with gallstones who were acutely infused with chenodeoxycholic acid, ursodeoxycholic acid, or cholic acid were examined for the propensity toward the formation of a liquid crystalline mesomorphic phase when cholesterol gallstones were incubated in these bile acids. Bile taken from patients infused with ursodeoxycholic acid was found to be enriched in ursodeoxycholic acid; mesophase formation was detected in these samples but not in bile from patients infused with chenodeoxycholic acid or cholic acid.

Keyphrases 0 Cholesterol -gallstone dissolution in human bile, effect of bile acid composition 0 Gallstone dissolution-human bile, effect of bile acid composition 0 Bile acids-mesophase formation during cholesterol gallstone dissolution