Effect of antacids on the bioavailability of diflunisal in the fasting and postprandial states
β Scribed by Tobert, J A; DeSchepper, P; Tjandramaga, T B; Mullie, A; Buntinx, A P; Meisinger, M A P; Huber, P B; Hall, T L P; Yeh, K C
- Book ID
- 109843083
- Publisher
- Nature Publishing Group
- Year
- 1981
- Tongue
- English
- Weight
- 259 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0009-9236
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## Abstract Concomitant administration of antacid increased the maximum concentration (__Cp__~max~) and the area under the plasma concentrationβtime curve (AUC) of 100 mg oral dose of metoprolol by 25 per cent (__p__< 0.05) and 11 per cent (__p__ < 0.1) respectively. For atenolol the opposite effec
The pharmacokinetic disposition and relative bioavailability of sertindole administered as a tablet dosage form under fasting conditions, in the presence of food, in the presence of antacid, and as solution was studied in a four-way crossover in young healthy male volunteers. Overall, tablet dosing