Effect of aging on hepatic elimination of cimetidine and subsequent interaction of aging and cimetidine on aminopyrine metabolism
โ Scribed by George I. Henderson; K.Vincent Speeg Jr.; Roderick K. Roberts; Anthony Perez; Steven Schenker
- Book ID
- 115780280
- Publisher
- Elsevier Science
- Year
- 1988
- Tongue
- English
- Weight
- 846 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0006-2952
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Both cimetidine therapy and cirrhosis individually interfere with normal elimination of various drugs. Cimetidine is often prescribed in patients with cirrhosis but there is incomplete data on its effect on drug elimination in cirrhotics. The purpose of this study was to address this issue. Eight st
In a randomized, double-blind, cross-over experiment, 6 healthy consenting male subjects were administered cimetidine 600 mg or ranitidine 300 mg or placebo p.o. q12h x 2 days. Nicotine bitartrate was administered i.v. on day 2 (1 microgram/kg/min) x 30 min. After cimetidine mean nicotine total and