Both cimetidine therapy and cirrhosis individually interfere with normal elimination of various drugs. Cimetidine is often prescribed in patients with cirrhosis but there is incomplete data on its effect on drug elimination in cirrhotics. The purpose of this study was to address this issue. Eight st
Effect of cimetidine on renal and hepatic drug elimination: Studies with triamterene
โ Scribed by Muirhead, Murray R; Somogyi, Andrew A; Rolan, Paul E; Bochner, Felix
- Book ID
- 109843952
- Publisher
- Nature Publishing Group
- Year
- 1986
- Tongue
- English
- Weight
- 662 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0009-9236
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
In a randomized, double-blind, cross-over experiment, 6 healthy consenting male subjects were administered cimetidine 600 mg or ranitidine 300 mg or placebo p.o. q12h x 2 days. Nicotine bitartrate was administered i.v. on day 2 (1 microgram/kg/min) x 30 min. After cimetidine mean nicotine total and
In anesthetized rabbits, continuous infusion of methotrexate (MTX; 30 micrograms kg-1 min-1) established steady-state plasma concentrations for MTX and the metabolite 7-hydroxymethotrexate (7-OH-MTX) within 40 min. Fifty percent of the infused dose was eliminated unchanged by the kidneys and the ren