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Effects of cimetidine and ranitidine on hepatic drug metabolism

✍ Scribed by Breen, K J; Bury, R; Desmond, P V; Mashford, M L; Morphett, B; Westwood, B; Shaw, R G

Book ID
109843184
Publisher
Nature Publishing Group
Year
1982
Tongue
English
Weight
214 KB
Volume
31
Category
Article
ISSN
0009-9236

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In a randomized, double-blind, cross-over experiment, 6 healthy consenting male subjects were administered cimetidine 600 mg or ranitidine 300 mg or placebo p.o. q12h x 2 days. Nicotine bitartrate was administered i.v. on day 2 (1 microgram/kg/min) x 30 min. After cimetidine mean nicotine total and