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Effect of cimetidine on microsomal drug metabolism in man

✍ Scribed by J. Puurunen; E. Sotaniemi; O. Pelkonen


Publisher
Springer
Year
1980
Tongue
English
Weight
361 KB
Volume
18
Category
Article
ISSN
0031-6970

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In Dutch-belted rabbits, pregnancy caused several-fold decrease of in vitro hepatic microsomal aminopyrine, benzphetamine, and hexobarbital biotransformations. In pregnant Sprague-Dawley rats, various kinds of expressing the in vitro rates of hexobarbital biotransformation (per mg of microsomal prot

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Both cimetidine therapy and cirrhosis individually interfere with normal elimination of various drugs. Cimetidine is often prescribed in patients with cirrhosis but there is incomplete data on its effect on drug elimination in cirrhotics. The purpose of this study was to address this issue. Eight st