## Abstract The 46 kD isoform of the 2′3′‐cyclic nucleotide 3′‐phosphodiesterase (CNPi) was expressed in HeLa cells by transfection of its cDNA clone. The distribution of this polypeptide as mapped by indirect immunofluorescence and conventional epifluorescence microscopy appeared diffuse and gener
Effect of a functional single nucleotide polymorphism in the 2′,3′-cyclic nucleotide 3′-phosphodiesterase gene on the expression of oligodendrocyte-related genes in schizophrenia
✍ Scribed by Kazuya Iwamoto; Junko Ueda; Miki Bundo; Yoko Nakano; Tadafumi Kato
- Book ID
- 108962230
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 136 KB
- Volume
- 62
- Category
- Article
- ISSN
- 1323-1316
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Cyclic nucleotide phosphodiesterase (CNP) and glial fibrillary acidic protein (GFAP) are useful markers of myelin and astroglia, respectively. Two proteins with CNP activity are known to exist in brain and lymphoid tissues. They appear to be the products of several distinct but related messenger rib
In order to investigate the role of the myelin-associated enzyme 2' 3'cyclic nucleotide 3'-phosphohydrolase in the development of the myelin sheath, as well as genetic factors involving dysmyelinating disorders, we have recently isolated and sequenced cDNAs corresponding to the CNPase protein. In th
## Abstract The olfactory bulb (OB) presents a unique pattern of permanent acquisition of primary afferents and interneurons, but not much detail is known about the differentiation of its oligodendroglial cells. We studied the expression of 2′,3′‐cyclic nucleotide 3′‐phosphodiesterase (CNPase), a p