The absolute configuration at C-3 of A-factor, 2-(6\_methylheptanoyl)-3-hydroxymethyl-4-butanolide 2, was determined to be S by synthesizing (3S)-(+)-A-factor.
Effect of A-factor on the growth of asporogenous mutants of Streptomyces griseus, not producing this factor
β Scribed by Dr. A. S. Khokhlov; L. N. Anisova; I. I. Tovarova; E. M. Kleiner; I. V. Kovalenko; O. I. Krasilnikova; E. Ya. Kornitskaya; S. A. Pliner
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 705 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0233-111X
No coin nor oath required. For personal study only.
β¦ Synopsis
Abstract
Aβfactor C~13~H~22~O~4~ was shown to be not only the inductor of the biosynthesis of streptomycin in inactive mutants of Streptomyces griseus (Actinomyces streptomycini), but also the potent regulator of differentiation of the cells: it induces the formation of spores in asporogenous strains during their superficial and submerged growth. This is accompanied by morphological modifications in the course of growth of the colonies.
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