Effect of 5-iodouracil and 2,6-diaminopurine on passive avoidance task

✍ Scribed by Stanislav Reiniš

• Publisher: Springer
• Year: 1971
• Tongue: English
• Weight: 335 KB
• Volume: 19
• Category: Article
• ISSN: 0033-3158
• DOI: 10.1007/bf00403700

✦ Synopsis

The effect of two antimetabolites, 2,6-diaminopurine and 5-iodouracil on passive avoidance learning was studied in male albino mice. The drugs were injected intracranially 48 h, 24 h or 2 h before and 1 h, 2 h or 24 h after the acquisition trial. The injection of 5-iodouracil 2 h before the acquistion trial or I h after it impairs the performance in the same experimental situation of the animals tested 48, 72 h or 1 week after. The same impairment of performance appears after the injection of 2,6-diaminopurine performed 24 and 2 h before or 1 h after the acquisition trial. The effect of these substances is probably caused by the interference with the metabolism of nucleic acids during learning.