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Effect of Choto-san, a Kampo medicine, on impairment of passive avoidance performance in mice

✍ Scribed by Mitsutoshi Yuzurihara; Kazuhiro Goto; Akira Sugimoto; Atsushi Ishige; Yasuhiro Komatsu; Yutaka Shimada; Katsutoshi Terasawa

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
52 KB
Volume
13
Category
Article
ISSN
0951-418X

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✦ Synopsis

In mice with procephalic ischaemia loading, disrupted passive avoidance retention performance was dose-dependently improved by Choto-san, but this effect was antagonized by NAN-190, a serotonin 1A receptor antagonist. In mice with decreased intracerebral serotonin concentration, Choto-san prevented disturbance in acquiring a passive avoidance response after scopolamine administration, but did not influence the decreased serotonin concentration. These results suggested that Choto-san showed the anti-amnestic effect based on the stimulation of serotonin 1A receptors.

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The present study was designed to clarify whether dopaminergic systems are involved in the eects of dynorphin A-(1-13), an endogenous k-opioid receptor agonist, on the galanin-induced impairment of passive avoidance learning in mice. Galanin (0Á3 mg, i.c.v.) shortened step-down latency of passive av