Comparative effects of S9977-2 versus tacrine on passive avoidance learning and psychomotor activity
✍ Scribed by X. A. Alvarez; R. Zas; L. Fernández-Novoa; M. García; E. Polo; S. Détolle-Sarbach; D. Guez; R. Cacabelos
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 226 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0885-6222
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✦ Synopsis
We have studied the time-and dose-dependent eects of S9977-2 versus tacrine (THA) on psychomotor activity (PMA) and passive avoidance learning (PAL) in intact 3-month-old rats. No signi®cant changes were observed in the levels of PMA in animals tested 0, 30 and 60 min after i.p. injections of S9977-2 (0 . 125 mg/kg) or THA (1 mg/kg). In a PAL maze paradigm, S9977-2 and THA, administered 30, 60 and 120 min before testing, induced time-dependent improvements in learning indices, with maximum eects during the ®rst hour after administration. In the dose± response study, S9977-2 (0 . 005, 0 . 025 and 0 . 125 mg/kg) tended to increase and THA (0 . 33, 1 and 3 mg/kg) to decrease PMA scores while the two compounds improved learning in a progressive dose-related manner. The present results indicate that S9977-2 and THA exert opposite actions on exploratory behaviour, S9977-2 increasing this parameter and THA decreasing it, and that both molecules improve learning in a similar time-and dosedependent manner. On a molar basis S9977-2 is 10±20 times more potent than THA in enhancing learning acquisition.