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Ectopic cytoplasmic expression of β-catenin carrelates with cyclin D1 overexpression in pancreatic cancer

✍ Scribed by Marco Ramadani; Qilu Ciao; Frank Gansauge; Susanne Gansauge; Gerd Leder


Book ID
119429094
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
183 KB
Volume
120
Category
Article
ISSN
0016-5085

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Reduced membranous and ectopic cytoplasm
✍ Qilu Qiao; Marco Ramadani; Susanne Gansauge; Frank Gansauge; Gerd Leder; Hans G. 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 French ⚖ 292 KB 👁 1 views

␤-Catenin is a component of the E-cadherin-catenin cell adhesion complex. It plays also a role in intracellular signaling and can function as an oncogene when it binds to the T-cell factor 4 (Tcf4)-binding site in the promoter region of cyclin D1 and transactivates genes after translocation to the n