𝔖 Bobbio Scriptorium
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Easy access to α-amino β-oxo esters from β-enamino esters

✍ Scribed by Elena Felice; Stefania Fioravanti; Lucio Pellacani; Paolo A. Tardella

Book ID
104261543
Publisher
Elsevier Science
Year
1999
Tongue
French
Weight
248 KB
Volume
40
Category
Article
ISSN
0040-4039

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✦ Synopsis

N-Substituted a-amino 13-oxo esters have been obtained by amination of 13-enamino esters with ethyl N-[(4-nitrobenzenesuiphonyl)oxy]carbamate (NsONHCOzEt), in the absence of added bases. The use of optically active pvrrolldines with (72 symmetry as ehiral auxiliaries induces diastereoselectivities up to 80°6.

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✍ Saı̈d Boukhris; Abdelaziz Souizi 📂 Article 📅 2003 🏛 Elsevier Science 🌐 French ⚖ 96 KB

The halohydrins prepared from epoxide esters, were treated with hydroxylamine derivatives. In subsequent reaction with NaOH/K 2 CO 3 /Bu 4 NHSO 4 the N-protected b-halo a-aminoesters thus obtained were converted into N-hydroxy ariridine 2-carboxylic esters in good yields.