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Diastereo and enantioselective entry to β-amino esters by hydride reduction of homochiral β-enamino esters.

✍ Scribed by Cristina Cimarelli; Gianni Palmieri; Giuseppe Bartoli


Book ID
103977015
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
298 KB
Volume
5
Category
Article
ISSN
0957-4166

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Chiral cyclic β-amino esters. Part II: S
✍ J. Blot; A. Bardou; C. Bellec; M.-C. Fargeau-Bellassoued; J.P. Célérier; G. Lhom 📂 Article 📅 1997 🏛 Elsevier Science 🌐 French ⚖ 182 KB

Catalytic and chemical reductions of chiral pyrrolidine 13-enamino esters provides corresponding [3-amino esters with good to moderate diastereomer excesses. The unexpected major diastereomer 5 comes from a reduction process which amounts to an anti hydrogen addition.