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Early treatment suppresses the development of spike-wave epilepsy in a rat model

✍ Scribed by Hal Blumenfeld; Joshua P. Klein; Ulrich Schridde; Matthew Vestal; Timothy Rice; Davender S. Khera; Chhitij Bashyal; Kathryn Giblin; Crystal Paul-Laughinghouse; Frederick Wang; Anuradha Phadke; John Mission; Ravi K. Agarwal; Dario J. Englot; Joshua Motelow; Hrachya Nersesyan; Stephen G. Waxman; April R. Levin

Book ID
109110660
Publisher
Wiley (Blackwell Publishing)
Year
2008
Tongue
English
Weight
494 KB
Volume
49
Category
Article
ISSN
0013-9580

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πŸ“œ SIMILAR VOLUMES

CNQX, a new non-NMDA receptor antagonist
CNQX, a new non-NMDA receptor antagonist, reduces spike wave discharges in the WAG/Rij rat model of absence epilepsy
✍ G.M.J. Ramakers; B.W.M.M. Peeters; J.M.H. Vossen; A.M.L. Coenen πŸ“‚ Article πŸ“… 1991 πŸ› Elsevier Science 🌐 English βš– 330 KB

The effects on seizures, EEG and behavior of the non-NMDA receptor antagonist CNQX (6-cyano-7-nitroquinoxaline-2,3-dione), were studied in the WAG/Rij rat with absence epilepsy. Intracerebroventricular injections (10, 50, and 100 nmol/5 microliters CNQX) showed that CNQX decreases the number of spik