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The selective GABAB antagonist CGP-35348 blocks spike-wave bursts in the cholesterol synthesis rat absence epilepsy model

โœ Scribed by Kris A. Smith; Robert S. Fisher


Book ID
113128453
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
475 KB
Volume
729
Category
Article
ISSN
0006-8993

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CNQX, a new non-NMDA receptor antagonist
โœ G.M.J. Ramakers; B.W.M.M. Peeters; J.M.H. Vossen; A.M.L. Coenen ๐Ÿ“‚ Article ๐Ÿ“… 1991 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 330 KB

The effects on seizures, EEG and behavior of the non-NMDA receptor antagonist CNQX (6-cyano-7-nitroquinoxaline-2,3-dione), were studied in the WAG/Rij rat with absence epilepsy. Intracerebroventricular injections (10, 50, and 100 nmol/5 microliters CNQX) showed that CNQX decreases the number of spik