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Early gene responses associated with transforming growth factor-β1 growth inhibition and autoinduction in MCF-7 breast adenocarcinoma cells

✍ Scribed by Corinne Lafon; Philippe Mazars; Marina Guerrin; Nadia Barboule; Jean-Yves Charcosset; Annie Valette

Book ID
116106241
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
667 KB
Volume
1266
Category
Article
ISSN
0167-4889

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To analyze transforming growth factor-b (TGF-b) response during MCF-7 cell progression, early passage (MCF-7E, õ200 passage) and late passage (MCF-7L, ú 500 passage) cells were compared. MCF-7E cells showed an IC 50 of Ç10 ng/ ml of TGF-b1, whereas MCF-7L cells were insensitive. MCF-7E cells contain