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Antiproliferative effect of phorbol esters on MCF-7 human breast adenocarcinoma cells: Relationship with enhanced expression of transforming growth-factor-β1

✍ Scribed by Marina Guerrin; Hervé Prats; Philippe Mazars; Annie Valette


Book ID
119121546
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
395 KB
Volume
1137
Category
Article
ISSN
0167-4889

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To analyze transforming growth factor-b (TGF-b) response during MCF-7 cell progression, early passage (MCF-7E, õ200 passage) and late passage (MCF-7L, ú 500 passage) cells were compared. MCF-7E cells showed an IC 50 of Ç10 ng/ ml of TGF-b1, whereas MCF-7L cells were insensitive. MCF-7E cells contain