DPC4/SMAD4 is a candidate tumor suppressor gene with a strikingly high frequency of gene alterations in pancreatic cancer that suggests a discrete role for DPC4 in these tumors. DPC4 tumor-suppressive function has been implicated to mediate the transforming growth factor-b (TGFb)±suppressive pathway
✦ LIBER ✦
DPC4 (SMAD4) mediates transforming growth factor-β1 (TGF-β1) induced growth inhibition and transcriptional response in breast tumour cells
✍ Scribed by Winter, Johan P de; Roelen, Bernard AJ; Dijke, Peter ten; Burg, Bart van der; van den Eijnden-van Raaij, Adriana JM
- Book ID
- 110060638
- Publisher
- Nature Publishing Group
- Year
- 1997
- Tongue
- English
- Weight
- 536 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0950-9232
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