We and others have previously shown that in vitro conversion of Epstein-Barr virus (EBqnegative Burkitt lymphoma (BL) cell lines with the immortalizing 895-8 strain of EBV results in a marked elevation in levels of c-fgr proto-oncogene mRNA. We now show, using a nuclear run-off assay, that this indu
Early activation of the proto-oncogene c-fgr during Epstein-Barr virus immortalization
β Scribed by Okano, Motohiko; Davis, Jack R.; Brichacek, Beda; Yasuda, Norimasa; Purtilo, David T.
- Book ID
- 123299378
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- English
- Weight
- 436 KB
- Volume
- 64
- Category
- Article
- ISSN
- 0304-3835
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The proto-oncogene c-fgr is expressed at high levels in cell lines derived from lymphomas which are infected with Epstein-Barr virus (EBV) (Cheah eta/., 1986). mRNA extracted directly from biopsies of EBV-infected tissues was analyzed on Northern blots to determine if c-fgr is expressed during lymph
## Epstein-Barr virus (EBV)-carrying Burkitt lymphoma (BL) lines which maintain the phenotypic characteristics of the in vivo tumor cells are more sensitive to natural (NK), interferonactivated (IAK) and IL-2-activated (LAK) cytotoxicity than EBV-immortalized lymphoblastoid cell lines (LCL) of nor