Cancer cells often contain mutations that lead to the loss of retinoblastoma tumor suppressor (Rb) function and the activation of E2F-dependent transcription. As a result, proliferation is deregulated, and sensitivity to apoptotic stimuli is increased. In cell culture studies, the transcription fact
E1A – oncogene or tumor suppressor?
✍ Scribed by Steven M. Frisch
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- English
- Weight
- 145 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0265-9247
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