Immunohistochemistry was used to analyze samples of 40 newly diagnosed childhood acute lymphoblastic leukemias (ALL) for their expression of cyclins (D1, E, A), cyclindependent kinases (cdk2, cdk4) and tumor-suppressor genes (pRb, p16 INK4A ), in order to discover whether or not the expression of th
Checking in on Cds1 (Chk2): A checkpoint kinase and tumor suppressor
β Scribed by Clare H. McGowan
- Publisher
- John Wiley and Sons
- Year
- 2002
- Tongue
- English
- Weight
- 214 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0265-9247
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Parathyroid adenomas causing primary hyperparathyroidism (pHPT) frequently exhibit allelic loss of DNA markers on the short arm of chromosome 1, indicating the presence of one or more tumor-suppressor genes on 1p. Since the development of pHPT is enhanced in individuals exposed to ionizing radiation
Recent studies have shown that 24R,25-(OH) 2 D 3 mediates its effects on growth plate chondrocytes via membrane receptors. This study examined the roles of phospholipase A 2 (PLA 2 ) and cyclooxygenase (Cox) in the mechanism of action of 24R,25-(OH) 2 D 3 in resting zone chondrocytes in order to det
Loss of heterozygosity (LOH) on 3p is frequent in human renal cell carcinomas, lung cancers, and breast cancers. To define the region(s) on 3p that harbor presumptive tumor suppressor gene(s) for breast cancer, we examined 196 primary breast tumors for their patterns of LOH at 22 microsatellite mark