✦ LIBER ✦

E-cadherin as a tumor (invasion) suppressor gene

✍ Scribed by Walter Birchmeier

Publisher: John Wiley and Sons
Year: 1995
Tongue: English
Weight: 370 KB
Volume: 17
Category: Article
ISSN: 0265-9247
DOI: 10.1002/bies.950170203

No coin nor oath required. For personal study only.

✦ Synopsis

Diffuse-type gastric carcinomas show diminished cell-cell adhesion. A recent paper(') reports that 50% of these carcinomas contain mutations in the Ecadherin gene, resulting in the destruction of the calcium-binding sites of Ecadherin, and providing strong in vivo evidence that alterations in E-cadherin play a major role in the development of this particular type of cancer and the short survival of the patients.

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