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E-optimal designs for the Michaelis–Menten model

✍ Scribed by Holger Dette; Weng Kee Wong

Book ID
104303119
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
84 KB
Volume
44
Category
Article
ISSN
0167-7152

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✦ Synopsis

We construct locally E-optimal designs for the two parameter Michaelis-Menten model under various assumptions on the error structure. Illustrative examples are given and the performance of these designs are compared with D-optimal designs.

📜 SIMILAR VOLUMES

Design Issues for the Michaelis–Menten M
Design Issues for the Michaelis–Menten Model
✍ J. LÓPEZ-FIDALGO; WENG KEE WONG 📂 Article 📅 2002 🏛 Elsevier Science 🌐 English ⚖ 174 KB

We discuss design issues for the Michaelis}Menten model and use geometrical arguments to "nd optimal designs for estimating a subset of the model parameters, or a linear combination of the parameters. We propose multiple-objective optimal designs when the parameters have di!erent levels of interest