We discuss design issues for the Michaelis}Menten model and use geometrical arguments to "nd optimal designs for estimating a subset of the model parameters, or a linear combination of the parameters. We propose multiple-objective optimal designs when the parameters have di!erent levels of interest
Confidence bands for the Michaelis-Menten kinetic model
✍ Scribed by M. Tez
- Book ID
- 112939395
- Publisher
- Springer-Verlag
- Year
- 1991
- Tongue
- English
- Weight
- 331 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0932-5026
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract The Michaelis–Menten kinetics is fundamental in chemical and physiological reaction theory. The problem of parameter identification, which is not well posed for arbitrary data, is shown to be closely related to the Chebyshev sum inequality. This inequality yields sufficient conditions f
We construct locally E-optimal designs for the two parameter Michaelis-Menten model under various assumptions on the error structure. Illustrative examples are given and the performance of these designs are compared with D-optimal designs.
Consisting Of More Than 3,700 Articles, All Xpharm Content Is Commissioned By An Outstanding Editorial Board Led By Past Presidents Of Aspet, S.j. Enna And David B. Bylund, Ph. D. And Contributed By Nearly 600 Experts.