Dysidotronic acid, a new and selective human phospholipase A2 inhibitor from the sponge Dysidea sp.

✍ Scribed by Clelia Giannini; Cécile Debitus; Inmaculada Posadas; Miguel Payá; Maria Valeria D’Auria

• Book ID: 104210192
• Publisher: Elsevier Science
• Year: 2000
• Tongue: French
• Weight: 133 KB
• Volume: 41
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)00362-2

✦ Synopsis

A new bioactive sesquiterpenoid, named dysidotronic acid 1, with a rearranged drimane skeleton has been isolated from the sponge Dysidea sp. from Vanuatu islands, along with bolinaquinone 2. The chemical structure of 1 was determined on the basis of spectroscopic data. Dysidotronic acid significantly inhibited human synovial phospholipase A 2 (PLA 2 ) at 10 µM, with an IC 50 value of 2.6 µM and a higher selectivity and potency towards this enzyme than the reference inhibitor manoalide.