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Dynorphin1–8 and dynorphin1–9 are ligands for the κ-subtype of opiate receptor

✍ Scribed by Corbett, Alistair D.; Paterson, Stewart J.; McKnight, Alexander T.; Magnan, Jacques; Kosterlitz, Hans W.


Book ID
109727444
Publisher
Nature Publishing Group
Year
1982
Tongue
English
Weight
343 KB
Volume
299
Category
Article
ISSN
0028-0836

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Membrane-assisted receptor subtype selec
✍ Kiichiro Nakajima; Daniel Erne; John W. Bean; David F. Sargent; Robert Schwyzer; 📂 Article 📅 1988 🏛 Elsevier Science 🌐 French ⚖ 943 KB

Two analogs of dynorphin A-(1-13)~tridecapeptide (1) were prepared by conventional synthesis in solution with Isolation and characterization of intermediates. In [Phe8'12, Lys"]dynorphin A-(1-13)-tridecapeptide (2). the helix-breaking residue Pro-10 was replaced by Lys-10, and Ile-8 and Leu-12 were