Dynamics in Enzyme Catalysis

✍ Scribed by Christopher M. Cheatum, Amnon Kohen (auth.), Judith Klinman, Sharon Hammes- Schiffer (eds.)

• Publisher: Springer-Verlag Berlin Heidelberg
• Year: 2013
• Tongue: English
• Leaves: 217
• Series: Topics in Current Chemistry 337
• Edition: 1
• Category: Library

✦ Synopsis

Christopher M. Cheatum and Amnon Kohen, Relationship of Femtosecond–Picosecond Dynamics to Enzyme-Catalyzed H-Transfer. Cindy Schulenburg and Donald Hilvert, Protein Conformational Disorder and Enzyme Catalysis. A. Joshua Wand, Veronica R. Moorman and Kyle W. Harpole, A Surprising Role for Conformational Entropy in Protein Function. Travis P. Schrank, James O. Wrabl and Vincent J. Hilser, Conformational Heterogeneity Within the LID Domain Mediates Substrate Binding to Escherichia coli Adenylate Kinase: Function Follows Fluctuations. Buyong Ma and Ruth Nussinov, Structured Crowding and Its Effects on Enzyme Catalysis. Michael D. Daily, Haibo Yu, George N. Phillips Jr and Qiang Cui, Allosteric Activation Transitions in Enzymes and Biomolecular Motors: Insights from Atomistic and Coarse-Grained Simulations. Karunesh Arora and Charles L. Brooks III, Multiple Intermediates, Diverse Conformations, and Cooperative Conformational Changes Underlie the Catalytic Hydride Transfer Reaction of Dihydrofolate Reductase. Steven D. Schwartz, Protein Dynamics and the Enzymatic Reaction Coordinate.

✦ Table of Contents

Front Matter....Pages i-ix
Relationship of Femtosecond–Picosecond Dynamics to Enzyme-Catalyzed H-Transfer....Pages 1-39
Protein Conformational Disorder and Enzyme Catalysis....Pages 41-67
A Surprising Role for Conformational Entropy in Protein Function....Pages 69-94
Conformational Heterogeneity Within the LID Domain Mediates Substrate Binding to Escherichia coli Adenylate Kinase: Function Follows Fluctuations....Pages 95-121
Structured Crowding and Its Effects on Enzyme Catalysis....Pages 123-137
Allosteric Activation Transitions in Enzymes and Biomolecular Motors: Insights from Atomistic and Coarse-Grained Simulations....Pages 139-164
Multiple Intermediates, Diverse Conformations, and Cooperative Conformational Changes Underlie the Catalytic Hydride Transfer Reaction of Dihydrofolate Reductase....Pages 165-187
Protein Dynamics and the Enzymatic Reaction Coordinate....Pages 189-208
Back Matter....Pages 209-212

✦ Subjects

Catalysis; Protein Science; Theoretical and Computational Chemistry