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Dynamic force microscopy for imaging of viruses under physiological conditions

✍ Scribed by Ferry Kienberger; Rong Zhu; Rosita Moser; Christian Rankl; Dieter Blaas; Peter Hinterdorfer

Book ID
111775386
Publisher
BioMed Central
Year
2004
Tongue
English
Weight
591 KB
Volume
6
Category
Article
ISSN
1480-9222

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## Abstract Elucidating dynamic morphological changes of gene‐carrying vectors and their nucleic acid release under varying intracellular conditions has been a technical challenge. Atomic force microscopy (AFM) was used to observe nucleic acid/polymer polyplexes under endosomal and reducible cytoso