## Abstract We show how electron microscopy can be used to answer several critical issues in neurodegenerative disorders that course with the formation of aberrant filamentous structures. Thus, electron microscopy is a useful technique to study in vitro assembly of pathogenic proteins, to map the r
✦ LIBER ✦
Characterization by Atomic Force Microscopy of Alzheimer Paired Helical Filaments under Physiological Conditions
✍ Scribed by Moreno-Herrero, F.; Pérez, M.; Baró, A.M.; Avila, J.
- Book ID
- 118515930
- Publisher
- Biophysical Society
- Year
- 2004
- Tongue
- English
- Weight
- 558 KB
- Volume
- 86
- Category
- Article
- ISSN
- 0006-3495
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## Abstract Paired helical filaments (PHFs) are abnormal twisted filaments composed of hyperphosphorylated tau protein. They are found in Alzheimer's disease and other neurodegenerative disorders designated as tauopathies. They are a major component of intracellular inclusions known as neurofibrill