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DUSP26 is a transcriptional target of MYCN in neuroblastoma

✍ Scribed by Ma, Irene T.; Vasudevan, Sanjeev A.; Patel, Roma H.; Yang, Jianhua; Shohet, Jason M.; Chen, Zaowen; Fan, Yihui

Book ID: 122368846
Publisher: Elsevier Science
Year: 2013
Tongue: English
Weight: 61 KB
Volume: 217
Category: Article
ISSN: 1072-7515
DOI: 10.1016/j.jamcollsurg.2013.07.180

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Amplification of the MYCN gene is significantly associated with an unfavorable prognosis and rapid progression in human neuroblastoma tumors. One potential mechanism by which MYCN may cause these effects is by deregulating cell proliferation. Tissue culture experiments support a model in which MYC g