Duryne, a new cytotoxic agent from the marine sponge Cribrochalina dura
β Scribed by Amy E Wright; Oliver J McConnell; Shigeo Kohmoto; May S Lui; Winnie Thompson; Kenneth M Snader
- Publisher
- Elsevier Science
- Year
- 1987
- Tongue
- French
- Weight
- 150 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
β¦ Synopsis
Duryne, 1, a cytotoxic metabolite which inhibits the growth of both mouse and human tumor cell lines in vitro has been isolated from the marine sponge Cribrochalina dura. Its -structure has been assigned by spectral methods.
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Along with two known cheilanthane sesterterpene lactones, 1 and 2, eight new related sesterterpenes (3-10) and two new nor-sesterterpenes (11 and 12) have been isolated from the New Caledonian marine sponge Petrosaspongia nigra Bergquist 1995 (new genus, new species). Their structures were determine