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New cytotoxic sesterterpenes from the New Caledonian marine sponge Petrosaspongia nigra (Bergquist)

✍ Scribed by Luigi Gomez Paloma; Antonio Randazzo; Luigi Minale; Cécile Debitus; Christos Roussakis

Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
475 KB
Volume
53
Category
Article
ISSN
0040-4020

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✦ Synopsis

Along with two known cheilanthane sesterterpene lactones, 1 and 2, eight new related sesterterpenes (3-10) and two new nor-sesterterpenes (11 and 12) have been isolated from the New Caledonian marine sponge Petrosaspongia nigra Bergquist 1995 (new genus, new species). Their structures were determined from 1D and 2D NMR studies and mass spectral data. They exhibited cytoxicity against the NSCLC-N6 human bronchopulmunary non-small-cell-lung carcinoma cell lines.

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✍ Marie-Lise Bourguet-Kondracki; Arlette Longeon; Cécile Debitus; Michèle Guyot 📂 Article 📅 2000 🏛 Elsevier Science 🌐 French ⚖ 168 KB

Four new cytotoxic isomalabaricane sesterterpenes, aurorals 1-4, have been isolated from the New Caledonian marine sponge Rhabdastrella globostellata. Their structures were established by spectroscopic data including 1D and 2D techniques. These compounds were found to exhibit cytotoxic activity on K