Duplication of 1F and 1A2 genes in the vitamin D-binding protein (GC) system
โ Scribed by Toshihiro Yasuda; Koichiro Kishi
- Publisher
- Springer
- Year
- 1994
- Tongue
- English
- Weight
- 136 KB
- Volume
- 93
- Category
- Article
- ISSN
- 0340-6717
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๐ SIMILAR VOLUMES
The group-specific component (GC) was discovered in 1959, and in the same year a vitamin D binding protein (DBP) in human plasma was found; however, their identity was established as late as 1975. In the GC/DBP system three common alleles, GC\*1F, GC\*1S, and GC\*2, determine six GC phenotypes: 1F,
Common and rare Gc phenotypes were analyzed by agarose gel electrophoresis immunofixation and by isoelectric focusing immunofixation before and after neuraminidase treatment. There is a difference between Gc types with double-band and with single-band patterns. Neuraminidase affects only Gc types wi
Studies were performed in Hep3B hepatocytes to better elucidate the mechanisms regulating circulating levels of human groupspecific component (Gc). We measured changes in Gc messenger RNA (mRNA) synthesis and levels of secreted protein resulting from treatment of hepatocytes with cytokines and hormo