Characterization of mutants of the vitamin D-binding protein/group-specific component: molecular evolution of GC*1A2 and GC*1A3, common in some Asian populations
โ Scribed by I. Yuasa; A. Kofler; A. Braun; K. Umetsu; R. Bichlmaier; S. Kammerer; H. Cleve
- Publisher
- Springer
- Year
- 1995
- Tongue
- English
- Weight
- 538 KB
- Volume
- 95
- Category
- Article
- ISSN
- 0340-6717
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The group-specific component (GC) was discovered in 1959, and in the same year a vitamin D binding protein (DBP) in human plasma was found; however, their identity was established as late as 1975. In the GC/DBP system three common alleles, GC\*1F, GC\*1S, and GC\*2, determine six GC phenotypes: 1F,
For the study of group specific component (Gc) and phosphoglucomutase (PGM1) polymorphism, isoelectric focusing was performed on eleven tribal and non-tribal populations of Himachal Pradesh, India. They were chosen to illustrate interregional and intraregional variations. The subtype frequencies of