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Dual Loss of PI3Kα and PI3Kγ Leads to a Paradoxical Increase in AKT Activation and Physiological Hypertrophy

✍ Scribed by Danny Guo; Ratnadeep Basu; Fung L. Chow; Xiuhua Wang; Zamaneh Kassiri; Gavin Y. Oudit


Book ID
116340116
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
47 KB
Volume
16
Category
Article
ISSN
1532-8414

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## Abstract In response to metabolic stress, GLUT4, the most abundant glucose transporter, translocates from intracellular vesicles to the plasma membrane. This appears to play an important role in protecting cardiac myocytes from ischemic injury. To investigate the precise mechanisms of GLUT4 tran