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Loss of class IA PI3K signaling in muscle leads to impaired muscle growth, insulin response, and hyperlipidemia

✍ Scribed by Ji Luo; Cassandra L. Sobkiw; Michael F. Hirshman; M. Nicole Logsdon; Timothy Q. Li; Laurie J. Goodyear; Lewis C. Cantley


Book ID
116372447
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
690 KB
Volume
3
Category
Article
ISSN
1550-4131

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✍ Charu Dogra; Harish Changotra; Jon E. Wergedal; Ashok Kumar πŸ“‚ Article πŸ“… 2006 πŸ› John Wiley and Sons 🌐 English βš– 472 KB

## Abstract Phosphatidylinositol 3‐kinase (PI3K)/Akt and nuclear factor‐kappa B (NF‐κB) signaling pathways play a critical role in mediating survival signals. In this study we have investigated how loss of dystrophin (the primary cause of Duchenne muscular dystrophy) modulates the activation of PI3