## Abstract The ability to quantitatively predict the influence of a solubilization technology on oral absorption would be highly beneficial in rational selection of drug delivery technology and formulation design. Cyclodextrins (CDs) are cyclic oligosaccharides which form inclusion complexes with
Drug Salts and Solubilization: Modeling the Influence of Cyclodextrins on Oral Absorption
β Scribed by Ece Dilber Gamsiz; Avinash G. Thombre; Imran Ahmed; Rebecca Lyn Carrier
- Publisher
- Springer
- Year
- 2010
- Tongue
- English
- Weight
- 729 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0090-6964
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## Abstract A model was developed for predicting the influence of cyclodextrins (CDs) delivered as a physical mixture with drug on oral absorption. CDs are cyclic oligosaccharides which form inclusion complexes with many drugs and are often used as solubilizing agents. The purpose of this work is t
The influence of hydrotropic compounds on complex formation by 2-hydroxypropyl-beta-cyclodextrin (2-HP-beta-CD) was investigated with methyltestosterone (MeT). Various representatives of the lyotropic series were used for this purpose. Additive hydrotropic effects were observed for nicotinamide and