Oral delivery of hydrophilic, ionisable drugs remains a major challenge in drug development and a number of active pharmaceuticals fail to reach the market of oral drugs because of a lack of absorption and/or stability issues. One possible approach to improving the bioavailability of such drug candi
Correlation of in vitro and in vivo models for the oral absorption of peptide drugs
✍ Scribed by F. Föger; A. Kopf; B. Loretz; K. Albrecht; A. Bernkop-Schnürch
- Publisher
- Springer
- Year
- 2007
- Tongue
- English
- Weight
- 189 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0939-4451
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
A major goal of the pharmaceutical scientist is "nding a relationship between an in vitro characteristic of an oral dosage form and its in vivo performance. One such relationship between drug dissolution (or absorption) in vivo and that in vitro is known as an &in vitro}in vivo correlation' (IVIVC)
The kinetics of drug transfer from a buffered aqueous phase (compartment A) through a lipid phase (compartment B ) to another aqueous buffered phase (compartment C) are reported. These kinetics are obtained from an in vifm model system which in important respects mimics drug transfer during the abso