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Drug partitioning III. Kinetics of drug transfer in an in vitro model for drug absorption

✍ Scribed by James T. Doluisio; Joseph V. Swintosky

Publisher
John Wiley and Sons
Year
1965
Tongue
English
Weight
493 KB
Volume
54
Category
Article
ISSN
0022-3549

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✦ Synopsis

The kinetics of drug transfer from a buffered aqueous phase (compartment A) through a lipid phase (compartment B ) to another aqueous buffered phase (compartment C) are reported. These kinetics are obtained from an in vifm model system which in important respects mimics drug transfer during the absorptive process. Several kinetic cases were observed-namely, DA -DB, DA DB,

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