Incubation of (R)-tazofelone and (S)-tazofelone in rat, dog, and human liver microsomes demonstrated that the (R)-tazofelone enantiomer was more rapidly metabolized, with two diastereomeric sulfoxides as the major metabolites formed in all three species. The two diasteresomers epimerized at physiolo
Evaluation of SupermixTM as an in vitro model of human liver microsomal drug metabolism
β Scribed by Karthik Venkatakrishnan; Lisa L. von Moltke; David J. Greenblatt
- Publisher
- John Wiley and Sons
- Year
- 2002
- Tongue
- English
- Weight
- 100 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0142-2782
- DOI
- 10.1002/bdd.307
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